《痛风2016年（柳叶刀）上的指南》.pdfVIP

Seminar Gout Pascal Richette, Thomas Bardin Lancet 2010; 375: 318–28 Gout is a common arthritis caused by deposition of monosodium urate crystals within joints after chronic Published Online hyperuricaemia. It aff ects 1–2% of adults in developed countries, where it is the most common infl ammatory arthritis August 18, 2009 in men. Epidemiological data are consistent with a rise in prevalence of gout. Diet and genetic polymorphisms of DOI:10.1016/S0140- renal transporters of urate seem to be the main causal factors of primary gout. Gout and hyperuricaemia are associated 6736(09)60883-7 with hypertension, diabetes mellitus, metabolic syndrome, and renal and cardiovascular diseases. Non-steroidal See Editorial page 254 anti-infl ammatory drugs and colchicine remain the most widely recommended drugs to treat acute attacks. Oral Université P aris 7, UFR Médicale, Assistance corticosteroids could be an alternative to these drugs. Interleukin 1β is a pivotal mediator of acute gout and could Publique-Hôpitaux de Paris, become a therapeutic target. When serum uric acid concentrations are lowered below monosodium urate saturation Hôpital Lariboisière, point, the crystals dissolve and gout can be cured. Patient education, appropriate lifestyle advice, and treatment of Fédération de Rhumatologie, comorbidities are an important part of management of patients with gout. Paris, France (P Richette MD, Prof T Bardin MD) Correspondence to: Introduction longstanding hyperuricaemia. Hyperurica