自体免疫疾病.pptVIP

Rheumatoid Factors An autoantibody reactive with denatured human or rabbit IgG Generation of RFs in the following conditions: Autoimmune disorders: RA, SLE, Sjogren＇s syndrome, vasculitis Chronic inflammation Chronic infection Malignancy aging Some Disease Commonly Associated with Rheumatoid Factor Schistosomiasis Other chronic pulmonary diseases Malaria Sarcoid Kala-azar Chronic liver disease Trypanosomiasis Cryoglobulinemia Parasitic Infections Hypergammaglobulinemic purpura titers of antivival antibodies) Other Hyperglobulinemic States After vaccination (may yield falsely elevated Tumors after radiation therapy or chemotherapy Influenza Neoplasms Hepatitis salmonellosis Mononucleosis Subacute bacterial endocarditis Acquired immunodeficiency syndromes Brucellosis Viral Infections Syphilis Sjogren＇s syndrome Yaws Mixed connective tissue disease Leprosy Scleroderma Tuberculosis Systemic lupus erythematosus Chronic Bacterial infections Rheumatoid arthritis Filariasis Rheumatic Diseases False Positive Rheumatoid Factor Test Sarcoidosis 10 % Syphilis 10 % Hepatitis 25 % Viral infection 15 % Leprosy 25 % Subacute bacterial endocarditis 50 % Old age ( 65y/o) 35 % Biomarkers in Rheumatoid Arthritis Rheumatoid factor Anti-CCP (anti-cyclic citrullinated peptides) Ab The presence of anti-CCP Ab is the most accurate biomarker for RA in both selected and unselected cohorts Goals of RA Management Pain relief and inflammation reduction Activities of daily living and quality of life Longterm joint damage control or prevention Disease process interruption or modification Therapy related side effects avoidance 僵直性脊椎关节炎(AS) 全身红斑性狼疮 好发于20-40岁之年轻女性 女性与男性之比例约为10:1