Importance of Macrolides to Animal Medicine.pptVIP

Importance of Macrolides in Veterinary Medicine Mike Apley, DVM, PhD Diplomate, American College of Veterinary Clinical Pharmacology Veterinary Diagnostic and Production Animal Medicine Iowa State University Macrolides in Veterinary Medicine 14 member ring erythromycin 16 member ring tylosin, tilmicosin Macrolide Susceptibility Testing The macrolide breakpoints reported here are adapted from the NCCLS M31-A2 document. The extended range information reflects extended dilutions used by some diagnostic laboratories utilizing microwell dilution systems. Of the macrolides, only tilmicosin has NCCLS validated breakpoints for veterinary applications. NCCLS macrolide breakpoints Label Applications Label applications in this presentation are adapted from labels as presented in the Compendium of Veterinary Products (North American Compendiums). The listing of a label application does not indicate the frequency or extent of use in animals. Label Applications in Food Animals Tylosin Label Indications Tylosin Injectable solution In beef cattle and nonlactating dairy cattle: indicated for use in the treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Actinomyces pyogenes; foot rot (necrotic pododermatitis) and diphtheria caused by Fusobacterium necrophorum, and metritis caused by Actinomyces pyogenes. Tylosin Injectable solution In swine: indicated for use in the treatment of swine arthritis caused by Mycoplasma hyosynoviae, swine pneumonia caused by Pasteurella spp., swine erysipelas caused by Erysipelothrix rhusiopathiae, acute swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae when followed by appropriate medication in the drinking water and/or feed. Tylosin Phosphate Feed Additive Beef Cattle: For reduction of incidence of liver abscesses caused by Fusobacterium necrophorum and Actinomyces pyogenes. Tylosin Phosphate Feed Additive Swine: For increased rat