Research Impropriety.pptVIP

Research Impropriety Alan K. Jacobson, MD ACOS/RD Loma Linda VAMC What have we covered so far? Responsible Institutions Responsible IRB Committees Responsible Investigators Responsible Auditing and Monitoring So what more could one ask for? Murphy’s Law If anything can go wrong, it will. Major John P. Stapp, M.D. Not well known in the compliance literature Human Guinea Pig, 1949 632 mph, 46.2Gs force “our good safety record was due to a firm belief in Murphy’s Law and in the necessity to try and circumvent it.” Died age 89 of natural causes So who was Murphy? Captain Edward A. Murphy Edwards AFB Engineer on project MX981 - deceleration When technician wired a transducer incorrectly - “If there is any way to do it wrong, he’ll find it.” Recorded by George E. Nichols, Northrop project manager, who kept a list of laws. Colonel John P. Stapp, M.D. “… a firm belief in Murphy’s Law and in the necessity to try and circumvent it.” The Essence of Local Accountability Research Impropriety Why does it occur? What is it? How should it be managed? Can it be prevented? Is there any good news? Research Impropriety “Does medicine have a culture that turns a blind eye to research misconduct?” Research Impropriety:Why does it occur? Why wouldn’t it happen? It happens in all other human activities. Pressure to publish. Inadequate training. Not taught good practice. Indeed, sometimes taught the opposite. Does sloppy behaviour spill over to fraud? You can get away with it. The system works on trust. Research Impropriety: What is it?Multitude of Terms Research or Scientific Impropriety Misconduct Misbehavior Noncompliance Fraud Sloppy science / research Junk science / research “Egregious abrogation of investigator responsibilities” “Scientists behaving badly” “Scientists Behaving Badly” Research on Research Integrity (Office of Research Integrity/NIH) Brian C. Martinson and colleagues 3,600 surveys to NIH funded scientists 1,768 (52%) usable responses % of scientists who say t