雌激素与创面愈合.docVIP

雌激素与创面愈合 作者：程 飚 ，付小兵，盛志勇 （.广州军区总医院整形外科，广东广州 510010） 摘要: 皮肤的愈合过程十分复杂，包括炎症细胞的聚集、基质沉积、再上皮化以及成熟瘢痕形成等过程。年龄常常影响着上皮愈合，其造成的急、慢性创面愈合难题加重了社会的负担。皮肤是雌激素作用的终末靶器官，它能够在很多方面与皮肤的功能相关，包括表皮、真皮、血管、毛囊和皮脂腺等。近年来的研究显示，老年男性或女性创面愈合局部应用雌激素能加速愈合过程。因此，雌激素在创面愈合中的作用十分重要。本文回顾了雌激素在创面愈合多个阶段―――炎症、增殖和塑形期的作用。但目前对雌激素在创面愈合中作用的系统研究仍然很少。进一步了解雌激素在创面愈合中的作用将有助于改善创面修复的能力。 关键词: 创面;愈合;激素;皮肤 Estrogen and wound healing CHENG Biao，FU Xiao-bing，SHENG Zhi-yong （Department of Plastic Surgery，Guangzhou General Hospital of Guangzhou Military Command，Guangzhou 510010，China） Abstract: Cutaneous wound healing is a complex process encompassing a number of overlapping events including inflammatory cell recruitment，matrix deposition，epithelialization and the formation of a mature scar.The effects of aging on the cutaneous wound healing process are profound，and the resulting acute and chronic wound morbidity imposes a sub-stantaial social and financial burden on health services.The skin appears to act as an end-organ target for estrogenic ac-tion.Estrogens clearly have an important function in many components of human skin including the epidermis，dermis，vas-culature，hair follicle and the sebaceuous gland etc.In recent years the effects of topical estrogen on cutaneous wound healing in healthy elderly men and women have been investigated.Hence，estrogen has significant roles in cutaneous wound healing.This review provides a survey of the literature that is available regarding the involvement and influence of estrogens on the various phases of cutaneous repair.inflammation，proliferation and remodelling.However，studies on es-trogen action in skin were limited.Further understanding of the complex interaction between estrogen and wound healing in the elderly is needed.Clinically our aim should be to restore the integrity and function ofwounded tissue as rapidly as pos-sible after injury and it is generally believed that a better understanding of the effects of estrogens on wo