《btg1008.tex-BIOINFORMATICS》.pdfVIP

BIOINFORMATICS Vol. 19 Suppl. 1 2003, pages i74–i80 DOI: 10.1093/bioinformatics/btg1008 Fast identification and statistical evaluation of segmental homologies in comparative maps 1 2 3,∗ Peter P. Calabrese , Sugata Chakravarty and Todd J. Vision 1Department of Mathematics, University of Southern California, Los Angeles, CA 90089, USA, 2 Department of Operations Research, and 3 Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Received on January 6, 2003; accepted on February 20, 2003 ABSTRACT ancestor. Two such segments are called segmental ho- Motivation: Chromosomal segments that share common mologs (SH). When dealing with an incompletely mapped D ancestry, either through genomic duplication or species genome, knowing that two segments are homologous is o w divergence, are said to be segmental homologs of one useful in that it suggests that other (unmapped) features