碱性离子液体催化下一锅三组分合成螺环吲哚衍生物有机化学.pdfVIP

2011 年第 31 卷 有 机 化 学 Vol. 31, 2011 第 5 期, 752～756 Chinese Journal of Organic Chemistry No. 5, 752～756 ·研究简报· 碱性离子液体催化下一锅三组分合成螺环吲哚衍生物 郭红云* 田金金 (浙江工业大学化学工程与材料学院 杭州 310014) 摘要 在碱性离子液体[H ＋ － N CH CH OH][CH COO ]催化作用下, 由靛红、丙二腈/氰乙酸乙酯和 β -二酮三组分“一锅 3 2 2 3 法”合成了一系列螺环吲哚类化合物, 产物的结构通过 1H NMR, IR 和 MS 表征. 该方法条件温和, 操作简单, 后处理 方便, 反应时间短, 对环境友好, 且催化剂廉价易得. 关键词 碱性离子液体; 一锅; 三组分; 螺环吲哚 One-Pot Three-Component Synthesis of Spirooxindoles Catalyzed by Basic Ionic Liquids Guo, Hongyun* Tian, Jinjin (College of Chemical Engineering and Material Science, Zhejiang University of Technology, Hangzhou 310014) Abstract A series of spirooxindoles were synthesized by a three component, one pot condensation of ＋ － isatin, malononitrile/ethyl cyanoacetate and β- diketone using [H N CH CH OH][CH COO ] as a basic 3 2 2 3 1 ionic liquid catalyst. The products were identified by H NMR, IR and MS techniques. This method has some distinct advantages such as mild reaction conditions, short reaction time, environmental friendliness and accessibility of catalyst. Keywords basic ionic liquid; one pot; three component; spirooxindole 吲哚类物质是非常常见的杂环化合物之一, 它表现 类化合物 . 我们以