An Atypical Presentation with Diagnostic Challenge of a Large Cell Neuroendocrine Cancer of Lung A Case Report and Review of the Literature.pdfVIP

SAGE-Hindawi Access to Research Lung Cancer International Volume 2011, Article ID 912098, 6 pages doi:10.4061/2011/912098 Case Report An Atypical Presentation with Diagnostic Challenge of a Large Cell Neuroendocrine Cancer of Lung: A Case Report and Review of the Literature Pavan Kumar Bhamidipati,1 Amanda Ribbeck,1 Goldees Liaghati-Nasseri,1 Ramesh Kumar,1 Babu Paidipaty B,2 and John Bartnik3 1 Internal Medicine, Synergy Medical Education Alliance, 1000 Houghton Avenue, Saginaw, MI 48602, USA 2 Pulmonary and Critical Care, Synergy Medical Education Alliance, 1000 Houghton Avenue, Saginaw, MI 48602, USA 3 Hematology and Oncology, Oncology Hematology Associates of Saginaw Valley, 5400 Mackinaw Road, Suite 4200, Saginaw, MI 48604-9533, USA Correspondence should be addressed to Pavan Kumar Bhamidipati, drbpavan@ and Goldees Liaghati-Nasseri, gliaghati@ Received 3 March 2011; Accepted 23 March 2011 Academic Editor: Akira Iyoda Copyright © 2011 Pavan Kumar Bhamidipati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Large-cell neuroendocrine carcinomas (LCNECs) are relatively rare and aggressive neoplasms of the lung with very poor prognosis. Even though they are included in the classification of nonsmall cell carcinomas, they have a biological behaviour and physiological response to treatment more like small cell carcinomas of lung. We report an atypical case presentation of LCNEC in a 51-year- old gentleman who presented with diffuse metastases to the thoracic and lumbar spine, brain, and liver, posing a diagnostic challenge. The primary small central lung tumor