Characterization of Kaposis Sarcoma-Associated Herpesvirus-Related Lymphomas by DNA Microarray Analysis.pdfVIP

SAGE-Hindawi Access to Research Leukemia Research and Treatment Volume 2011, Article ID 726964, 11 pages doi:10.4061/2011/726964 Review Article Characterization of Kaposi’s Sarcoma-Associated Herpesvirus-Related Lymphomas by DNA Microarray Analysis Keiji Ueda, Eriko Ohsaki, Kazushi Nakano, and Xin Zheng Division of Virology, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan Correspondence should be addressed to Keiji Ueda, kueda@virus.med.osaka-u.ac.jp Received 26 June 2011; Accepted 2 September 2011 Academic Editor: Daniela Cilloni Copyright © 2011 Keiji Ueda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Among herpesviruses, γ-herpesviruses are supposed to have typical oncogenic activities. Two human γ-herpesviruses, Epstein- Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV), are putative etiologic agents for Burkitt lymphoma, nasopharyngeal carcinoma, and some cases of gastric cancers, and Kaposi’s sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma (PEL) especially in AIDS setting for the latter case, respectively. Since such two viruses mentioned above are highly species specific, it has been quite difficult to prove their oncogenic activities in animal models. Nevertheless, the viral oncogenesis is epidemiologically and/or in vitro experimentally evident. This time, we investigated gene expression profiles of KSHV-oriented lymphoma cell lines, EBV-oriented lymphoma cell lines, and T-cell leukemia cell lines. Both KSHV and EBV cause a B-cell-originated lymphoma, bu