Cross-Genome Comparisons of Newly Identified Domains in Mycoplasma gallisepticum and Domain Architectures with Other Mycoplasma species.pdfVIP

Hindawi Publishing Corporation Comparative and Functional Genomics Volume 2011, Article ID 878973, 13 pages doi:10.1155/2011/878973 Research Article Cross-Genome Comparisons of Newly Identified Domains in Mycoplasma gallisepticum and Domain Architectures with Other Mycoplasma species Chandra Sekhar Reddy Chilamakuri,1, 2 Adwait Joshi,2 Sane Sudha Rani,2 Bernard Offmann,1 and R. Sowdhamini2 1 Equipe de Bioinformatique, Laboratoire de Biochimie et Genetique Moleculaire, Universite de La Reunion, 15 avenue Rene Cassin, ´ ´ ´ ´ ´ ´ La Reunion, 97715 Saint Denis Messag Cedex 09, France ´ 2 National Centre for Biological Sciences, GKVK Campus, Bellary Road, Bangalore 560065, India Correspondence should be addressed to R. Sowdhamini, mini@ncbs.res.in Received 30 July 2010; Revised 21 February 2011; Accepted 23 May 2011 Academic Editor: G. Pesole Copyright © 2011 Chandra Sekhar Reddy Chilamakuri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Accurate functional annotation of protein sequences is hampered by important factors such as the failure of sequence search methods to identify relationships and the inherent diversity in function of proteins related at low sequence similarities. Earlier, we had employed intermediate sequence search approach to establish new domain relationships in the unassigned regions of gene products at the whole genome level by taking Mycoplasma gallisepticum as a specific example and established new domain relationships.