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Effect of Stress on Viral–Bacterial Synergy in Bovine Respiratory Disease Novel Mechanisms to Regulate Inflammation.pdf
Comparative and Functional Genomics
Comp Funct Genom 2005; 6: 244–250.
Published online in Wiley InterScience (). DOI: 10.1002/cfg.474
Conference Paper
Effect of stress on viral–bacterial synergy
in bovine respiratory disease: novel
mechanisms to regulate inflammation
1,2 2 # 3 3 3 2
P. D. Hodgson , P. Aich , A. Manuja , K. Hokamp , F. M. Roche , F. S. L. Brinkman , A. Potter ,
L. A. Babiuk2 2
and P. J. Griebel *
1Genome Prairie, Suite 115, 3553-31 St., NW, Calgary, AB, Canada T2L 2K7
2 Vaccine and Infectious Disease Organization, 120 Veterinary Road, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E3
3Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada V5A 1S6
*Correspondence to: Abstract
P. J. Griebel, Vaccine and
Infectious Disease Organization, The severity of bovine respiratory infections has been linked to a variety of
120 Veterinary Road, University factors, including environmental and nutritional changes, transportation, and social
of Saskatchewan, Saskatoon, SK, reorganization of weaned calves. Fatal respiratory infections, however, usually occur
Canada S7N 5E3. when a primary viral infection compromises host defences and enhances the severity
E-mail: griebelp@sask.usask.ca of a secondary bacterial infection. This viral–bacterial synergy can occur by a number
# of different mechanisms and disease challenge models have been developed to analyse
Current Address: Central
host responses during these respiratory infections. A primary bovine herpesvirus-1
Institute for Research on Buffalo,
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