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Immune Responses against Conserved and Variable Viral Epitopes.pdf
Joutnal fThero,uliiuiMriiicine. Vol 3. pp. 37-49 02000 OPA (O\errens Publl,her\ AssociatumJ N V
Reprmts available dmctly from the publ~chcr Pubhrhed by llcense under
Photocopy~ngperrn~ttedby license only the Gordon and Breach S c ~ e n c c
Publ~shersimpnnt.
Prmted In Ma1ay~1.1
Immune Responses Against Conserved and Variable Viral
Epitopes
B. BITTNER~S*and L.M. WAHL~
Institute of illgebra and ComnputationcdMarhemutics, Vienna Uiiiversit?;of Technolog?; Vienna, Austria aird h~17eoreticnlBiolog?; Instirure
for Advanced Study, Prir~ceton,Ne$cJersey
(hfinalform 22 May 2000)
We extend well-known mathematical models of viral infection to examine the response of
cytotoxic T lymphocytes (CTL) to both conserved and variable viral epitopes. Because most
viruses are subject to error-prone reproduction, CTL recognition may be faced with highly
variable epitopes, while other CTL epitopes may remain conserved across viral strains. In this
paper we examine the steady state conditions for a simple model of viral-immune system
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