Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2011, Article ID 438463, 10 pages doi:10.1155/2011/438463 Research Article Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth Patricia L. Semple,1 Marcia Watkins,1, 2 Virginia Davids,3 Alan M. Krensky,4 Willem A. Hanekom,3, 5 Gilla Kaplan,6 and Stanley Ress1, 7 1 Division of Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town 7925, South Africa 2 National Health Laboratory Service, Cape Town 8000, South Africa 3 South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7700, South Africa 4 National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-8322, USA 5 School of Child and Adolescent Medicine, University of Cape Town, Cape Town, South Africa 6 Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103-3535, USA 7 Groote Schuur Hospital, Cape Town 7925, South Africa Correspondence should be addressed to Stanley Ress, stan.ress@uct.ac.za Received 16 August 2010; Accepted 27 October 2010 Academic Editor: James Triccas Copyright © 2011 Patricia L. Semple et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ´ Background. While vaccination at birth with Mycobacterium bovis Bacilli Calmette-Gue