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维普资讯
Cellular M olecularImm unology 107
Review
Stem CellNiche，theM icroenvironmentandImmunological
Crosstalk
LawSujataandS．Chaudhuri，
Theconceptofstem cells，theirphysiolo calexistence，theintricateanatomicallocalization．theknown and the
unknown functions，andtheirexclusiveutilityforthepurposeofregenerativemedicine．areallnow encompassed
、’，itIlin an emergentquestion，h‘ow compatiblethesecellsareimmunologically?’Indeed．themedicalaspectsof
stem cellsaredependentonalargenumberofqueriesbasedonthebasicpropertiesofthecells．Ithasgreatlybeen
emphasizedtoprobeintothebasicresearchonstem cellsbeforeanysuccessfultherapeuticattemptsare made．One
Oftheintricateaspectsoftheadultstem cellsisitsimmunologicalbehaviorinrelatiOntOthemicroenvironmental
associates，htestromal cellsinthepresenceofasuitabletarget．Cellular＆MolecularImmunology．2OO8；5(2)：107．112．
KeyW ords：stem cellniche，stromalimmunology
Introduction regenerative biology nad medicine htat cna eventually
explore hte world of physiological mystery for the
Ithas been predicted thatthere has been a continuous developingorgnaismsincludinghighermammals(1)．Men
rae no exceptionsto htese na d hte stem cellreserach is
crosstalk inbetweenthestem cellsandhteirmachinery the
expected to unearth several unexplained phenomena those
niche，whilethestromalpopulationinthemicroenvironment
leadtoinitiateseveralintricatediseaseconditionsr2。41．Stem
(ME)mediateapotentialprotectivenetworktopr
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