Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists.PDFVIP

REPORT Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists KUAN-MING CHEN,1,2,3 EDGAR CAMPBELL,1,2,3 RADHA RAMAN PANDEY,1,2 ZHAOLIN YANG,1,2 ANDREW A. MCCARTHY,1,2 and RAMESH S. PILLAI1,2 1European Molecular Biology Laboratory, Grenoble Outstation, 38042 Grenoble Cedex 9, France 2Unit for Virus Host-Cell Interactions, University Grenoble Alpes-EMBL-CNRS, 38042 Grenoble Cedex 9, France ABSTRACT Piwi-interacting RNAs (piRNAs) guide Piwi argonautes to their transposon targets for silencing. The highly conserved protein Maelstrom