Nuclear and cytoplasmic localizations of the adenomatous polyposiscoliprotein.PDFVIP

Proc. Natl. Acad. Sci. USA Vol. 94, pp. 3034–3039, April 1997 Cell Biology Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein (tumor suppressorimmunofluorescence microscopycellular fractionationcolon cancer) KRISTI L. NEUFELD * AND RAYMOND L. WHITE Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112 Contributed by Raymond L. White, December 31, 1996 ABSTRACT Mutation of the adenomatous polyposis coli As seen by others in different cells (10), we have seen a (APC ) gene is an early step