Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.PDFVIP

The EMBO Journal Vol.17 No.2 pp.554–564, 1998 Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein Judith Roth1,2, Matthias Dobbelstein3,4, creating an autoregulatory feedback loop (Wu et al., 1993). Deborah A.Freedman1, Thomas Shenk3 and hdm2 is overexpressed in a variety of human tumors Arnold J.Levine1,5 (Oliner et al., 1992; Bueso-Ramos e