Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan.PDFVIP

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan a a a,b,1 Anil Rana , Michael Rera , and David W. Walker aDepartment of Integrative Biology and Physiology, and bMolecular Biology Institute, University of California, Los Angeles, CA 90095 Edited by Barry Ganetzky, University of Wisconsin, Madison, WI, and approved March 15, 2013 (received for review September 24, 2012) Aberrant protein aggregation and mitochondrial dysfunction have undergo prote