动脉粥样斑块破裂进展(炎症、信号转导他汀).ppt

Statin Therapy: CRP水平与死亡率 Horne BD et al. J Am Coll Cardiol 2000;36:1774-1780. CRP Tertiles Statins Low Mortality (%) CRP Tertiles No Statins Medium High Low Medium High P Trend = 0.94 P Trend 0.0001 Withdrawal of statins:  增加ACS患者近期心血管事件发生率 Circulation 2002; 105:1446-1542 冠心病何时开始他汀类药物治疗? Stating Time Time From Coronary Event (months) 1 2 3 4 5 6 4S (n=4444) L-CAD (n=135) MIRACL (n=3086) PROSPER (n=5804) HPS (n=20536) PACT (n=3408) A to Z (n=4500) CARE (n=4159) LIPID (n=9014) PROVE-IT (n=4160; before March 8, 2004) Ongoing Completed AVERT (n=341) FLORIDA (n=540) hs-CRP (mg/L) St