一药物代谢发展简史资料.pptVIP

浙江大学药学院 曾苏/药物分析与药物代谢研究室 药物大多是外来分子，进入人体后生物体的防御系统必然对这些外源物有所反应。一些药物以原形从人体排泄，然而大多数药物为了易于排泄需要进行结构修饰。这些结构修饰的过程称为“药物代谢”（drug metabolism）, 也称为“生物转化”（biotransformation）。 In the urine eliminated the next morning was found to be unusually acidic, even after being allowed to stand 12 hours after evaporation ...after the residue was mixed with hydrochloric acid and allowed to stand, a large amount of long prismatic brown crystals was formed, which did look like benzoic acid. Another portion, which had been concentrated to a syrupy thickness, formed a magma乳浆状of crystalline plates