病理生理学课件精要.pptVIP

Mechanisms of Oncogene Activation ORF RS Proto-oncogene ORF RS ORF RS ORF RS mutation amplification ORF RS RS Re-arrangement deletion Point mutation Ras 15-20% K-ras N-ras H-ras carcinomas 30%:lung adenocarcinomas 50% colon carcinomas 90%:pancreatic carcinomas Blood malignancies Exon 12 insersion Partial karyotypes of trypsin-Giemsa-banded metaphase cells depicting nonrandom chromosomal rearrangements observed in lymphoid malignant diseases. t(4;11)(q21;q23) in ALL t(1;19)(q21;p13) in pre-B cell ALL t(8;14)(q24;q32) in B-cell ALL and Burkitts lymphoma inv(14)9q11q32) in T-cell leukemia/lymp