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acetyl-stronglstrong-carnitine improves pain, nerve regeneration, and.pdf

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acetyl-stronglstrong-carnitine improves pain, nerve regeneration, and

E m e r g i n g T r e a t m e n t s a n d T e c h n o l o g i e s O R I G I N A L A R T I C L E Acetyl-L-Carnitine Improves Pain, Nerve Regeneration, and Vibratory Perception in Patients With Chronic Diabetic Neuropathy An analysis of two randomized placebo-controlled trials ANDERS A.F. SIMA, MD, PHD1 ANTONINO AMATO, MD4 trials have been undertaken in the past MENOTTI CALVANI , MD2 FOR THE ACETYL-L-CARNITINE STUDY (rev. in 3,4). Most notably, numerous al- MUNISH MEHRA, PHD3 GROUP* dose reductase inhibitor (ARI) trials have been conducted with disappointing re- sults (5–8). Because of adverse drug ef- fects, several ARI developments were abandoned (4,9). Multicenter trials with OBJECTIVE — We evaluated frozen databases from two 52-week randomized placebo- -lipoic acid have shown small improve- controlled clinical diabetic neuropathy trials testing two doses of acetyl-L-carnitine (ALC): 500 ments in nerve conduction velocities, but and 1,000 mg/day t.i.d. no effects on neuropathy disability scores RESEARCH DESIGN AND METHODS — Intention-to-treat patients amounted to (4,10). 1,257 or 93% of enrolled patients. Efﬁcacy end points were sural nerve morphometry, nerve Ace