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aminoacids in the synthesis of heterocyclic systems the.pdf

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aminoacids in the synthesis of heterocyclic systems the

Molecules 2001, 6, 267-278 molecules ISSN 1420-3049 Aminoacids in the Synthesis of Heterocyclic Systems: The Synthesis of Triazinoquinazolinones, Triazepinoquinazolinones and Triazocinoquinazolinones of Potential Biological Interest 1,a 1,* 1 1 2,b A.M.Sh.El-Sharief , Y.A.Ammar , M.A.Zahran , A.H.Ali and M.S.A.El-Gaby 1Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr-City 11884, Cairo, Egypt. aE-mail: ahmed_shab@; Fax: 002(02)2629356 2Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Assiut 71524 Egypt. bE-mail: m_elgaby@, Fax: +20 88 325436 *Author to whom correspondence should be addressed; E-mail: yossry@ Received: 5 April 2000; in revised form 29 August 2000 / Accepted: 1 February 2001 / Published: 28 February 2001 Abstract: A number of novel triazinoquinazolinones (5b,c and 8), triazepinoquinazoli- nones(5a, 6b, 7 and 9) and triazocinoquinazolinones (6a and 10) were obtained via nucleophilic interaction of 3-aminoquinazolinone derivatives 3 with different reagents. Keywords: Triazinoquinazolinones, triazepinoquinazolinones, triazocinoquinazolinones, biological activity Introduction Varied biological activities have been attributed to quinazoline compounds, including analgesic, antiinflammatory, antipyretic [1-3], antimicrobial [4], anticonvulsant [5], fungicidal [6], anti- depressant and other central nervous system affecting activities [7]. The use of aminoacids as starting materials for the design and synthesis of new quinazoline comp