肿瘤免疫课件精要.ppt

1901年以来，免疫学领域研究中有19项获得Nobel奖 例如: 人类血型的发现 (1930) 移植免疫 (1991) The immune system T cells 两种类型: Helper T cells (Th): activates other cells Cytotoxic T cells (Tc): can kill other cells T 细胞识别抗原需有MHC分子的参与 Presentation of antigens to T cells Proteins (peptides) from inside the cell are presented by MHC I molecules to Tc cells. Proteins (peptides) from the outside of cells are presented by MHC II molecules to Th cells. MHC I on almost all cells MHC II on specialized antigen-presenting cells T 细胞的抗肿瘤作用 双重激活信号 第一信号：APC细胞的递呈及TCR复合物的形成 第二信号：APC共刺激因子（B7、粘附分子等）参与 第一信号中，T细胞活化受MHC分子限制 -