Premature ageing in mice expressing defective mitochondrial.pdfVIP

letters to nature EIAV–LacZ control (n ¼ 7). Each mouse was injected with a total dosage of 90 ml of viral (rhIGF-I) for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst. Rev. 3, solution. Six sites per hindlimb muscle were injected with 5 ml per site. CD002064 (2002). 22. Azzouz, M. et al. Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino Behavioural analysis acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene We analysed a rotarod task of the SOD1 mice by an Economex Rotarod instrument expression, dopamine production, and functional improvement in a rat model of Parkinson’s disease. (Colombus Instruments) every ten days during the light phase of the 12 h light/12 h dark J. Neurosci. 22, 10302–10312 (2002). cycle. We performed three trials, and recorded the longest duration on the rod for every 23. Bienemann, A. S. et al. Long-term replacement of a mutated nonfunctional CNS gene: reversal of mouse. The timer is stopped when the mice fall from the rod or after an arbitrary limit of hypothalamic diabetes insipidus using an EIAV-based lentiviral vector expressing arginine 180 s. Footprint analysis was also performed. Mouse hind paws were covered with ink to vasopressin. Mol. Ther. 7, 588–596 (2003). record walking patterns during continuous locomotion, and stride length was measured.