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INSIGHT REVIEW NATURE|Vol 444 |14 December 2006 |doi:10.1038/nature05485
Inflammation and metabolic disorders
Gökhan S. Hotamisligil1
Metabolic and immune systems are among the most fundamental requirements for survival. Many
metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been
evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are
highly integrated and the proper function of each is dependent on the other. This i
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