Inflammation and metabolic disorders - Harvard University.pdfVIP

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Inflammation and metabolic disorders - Harvard University.pdf

INSIGHT REVIEW NATURE|Vol 444 |14 December 2006 |doi:10.1038/nature05485 Inflammation and metabolic disorders Gökhan S. Hotamisligil1 Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This i

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