a novel o-naphtoquinone inhibits n-cadherin expression and blocks melanoma cell invasion via akt signaling：一种新的o-naphtoquinone通过akt信号通路抑制n-钙粘蛋白的表达和块黑色素瘤细胞浸润.pdfVIP

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a novel o-naphtoquinone inhibits n-cadherin expression and blocks melanoma cell invasion via akt signaling：一种新的o-naphtoquinone通过akt信号通路抑制n-钙粘蛋白的表达和块黑色素瘤细胞浸润.pdf

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a novel o-naphtoquinone inhibits n-cadherin expression and blocks melanoma cell invasion via akt signaling：一种新的o-naphtoquinone通过akt信号通路抑制n-钙粘蛋白的表达和块黑色素瘤细胞浸润

Toxicology in Vitro 27 (2013) 2076–2083 Contents lists available at ScienceDirect Toxicology in Vitro journal homepage: www.elsevier .com/locate/toxinvit A novel o-naphtoquinone inhibits N-cadherin expression and blocks melanoma cell invasion via AKT signaling Raquel Carvalho Montenegro a,⇑, Marne Carvalho de Vasconcellos b, Gleyce dos Santos Barbosa b, Rommel M.R. Burbano a, Luciana G.S. Souza c, Telma L.G. Lemos c, Letícia V. Costa-Lotufo d, Manoel Odorico de Moraes d a Instituto de Ciências Biológicas, Universidade Federal do Pará, Rua Augusto Corrêa 01-Guamá, Belém/PA, Brazil b Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Rua Alexandre Amorim, 330-Aparecida, Manaus/AM, Brazil c Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Campus do Pici, bloco 940 Bairro Pici, Fortaleza/CE, Brazil d Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Av. Cel. Nunes de Melo, 1127 – Rodolfo Teóﬁlo, Fortaleza/CE, Brazil a r t i c l e i n f o a b s t r a c t Article history: The down-regulation or loss of epithelial markers is often accompanied by the up-regulation of mesen- Received 21 January 2013 chymal markers. E-cadherin generally suppresses invasiveness, whereas N-cadherin promotes invasion Accepted 23 July 2013 and metastasis in vitro. The aim of this work is to investigate the role of biﬂorin, a naphthoquinone with Available online 1 August 2013 proven anticancer properties, on the expression of N-cadherin and AKT proteins in MDA-MB-435 invasive