a novel rapid and selective enzymatic debridement agent for burn wound management a multi-center rct：一种新型的快速和选择性的烧伤创面处理的多中心rct酶清创剂.pdfVIP

b u r n s 4 0 ( 2 0 14 ) 4 6 6 – 4 7 4 Available online at ScienceDirect journal homepage: /locate/burns A novel rapid and selective enzymatic debridement agent for burn wound management: A multi-center RCT Lior Rosenberg a,1, Yuval Krieger a,1, Alex Bogdanov-Berezovski a,1, Eldad Silberstein a,1, Yaron Shoham a, 1, Adam J. Singer b, 1,* a Department of Plastic and Reconstructive Surgery, Ben Gurion University, Faculty of Health Sciences, Beer-Sheba, Israel b Department of Emergency Medicine, Stony Brook University, Stony Brook, NY, United States a r t i c l e i n f o a b s t r a c t Article history: Objectives: Excisional debridement followed by autografting is the standard of care (SOC) for Accepted 9 August 2013 deep burns, but is associated with serious potential complications. Conservative, non- surgical and current enzymatic debridement methods are inefficiently slow. We determined Keywords: whether a non-surgical option of rapid enzymatic debridement with the debriding enzyme Burn wound NexoBridTM (NXB) would reduce need for surgery while achieving similar esthetic and Debridement functional outcomes as SOC. Eschar Methods: We conducted a multi-center, open-label, randomized, controlled clinical trial Eschar removal including patients aged 4-55 years with deep partial and full thickness burns covering 5- Escharectomy