a pathological reassessment of organ-confined, gleason score 6 prostatic adenocarcinomas that progress after radical prostatectomy：器官局限性病理评估，格里森评分6前列腺癌，前列腺癌根治术后的进展.pdf

Human Pathology (2009) 40, 1693–1698 /locate/humpath Original contribution A pathological reassessment of organ-confined, Gleason score 6 prostatic adenocarcinomas that progress after radical prostatectomy a b a,b,c,⁎ Hiroshi Miyamoto MD, PhD , David J. Hernandez MD , Jonathan I. Epstein MD aThe Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA b The Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA cThe Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA Received 4 March 2009; revised 27 April 2009; accepted 5 May 2009 Keywords: Summary Prior studies of radical prostatectomies have reported a small percentage of men with Radical prostatectomy; biochemical progression after radical prostatectomy showing organ-confined, Gleason Score 6. One Gleason score; might predict that this should virtually never occur. We identified 2551 (1983-2005) radical Biochemical progression prostatectomies coded by the urologists at our institution as pathologically organ-confined, Gleason score 6 cancer with more than 1 year of follow-up. We re-examined histopathogically the serially sectioned and completely embedded radical prostatectomy specimens of 38 men who developed