a population-based study of men with low-volume low-risk prostate cancer does african-american race predict for more aggressive disease：低风险前列腺癌患者的一项基于人群的研究非裔美国人种族预测更积极的疾病.pdfVIP

Original Study A Population-Based Study of Men With Low-Volume Low-Risk Prostate Cancer: Does African-American Race Predict for More Aggressive Disease? David Schreiber,1,2 Arpit Chhabra, 1,2 Justin Rineer,3 Jeremy Weedon,2 David Schwartz1,2 Abstract We used the Surveillance, Epidemiology, and End Results database to identify 1794 men with low-risk low- volume prostate cancer who underwent surgery. We compared the pathologic findings according to race and found no significant differences in pathologic stage or grade between African-American and Caucasian men. These data support the continued use of active surveillance in the African-American population. Background: Because of recent reports that suggested more pathologically aggressive disease in African-American (AA) men, we sought to compare pathologic features between AA and Caucasian-American men with low-risk, low-volume prostate cancer. Materials and Methods: We analyzed the Surveillance, Epidemiology, and End Results database for pathologic differences based on race. Data on all men who were diagnosed between 2010 and 2011 with prostate cancer, T1cN0M0, Gleason score of 6 (3þ3), prostate-specific antigen 10 ng/mL, via a 12-core biopsy and had 2 positive samples, and underwent radical prostatectomy were abstracted. Univariate and multi- variate logistic regression were performed to detect predictors for adverse pathology, which was primarily defined as pT2 and Gleason 4þ3, or pT3a and Gleason 3þ3 with positive margins, pT3a and Gleason 3þ4, or pT3b-pT4 with any Gleason score. Results: There were 1794 men who met the target study criteria. AA men were a median of 3 years y