原创力文档a prospective flexible-dose study of paliperidone palmitate in nonacute but symptomatic patients with schizophrenia previously unsuccessfully treated with oral antipsychotic agents：一个前瞻性的灵活剂量研究棕榈酸帕利哌酮在非急性症状性患者以前治疗失败的口服抗精神病药物治疗的精神分裂症.pdfVIP
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a prospective flexible-dose study of paliperidone palmitate in nonacute but symptomatic patients with schizophrenia previously unsuccessfully treated with oral antipsychotic agents：一个前瞻性的灵活剂量研究棕榈酸帕利哌酮在非急性症状性患者以前治疗失败的口服抗精神病药物治疗的精神分裂症
Clinical Therapeutics/Volume 36, Number 10, 2014
A Prospective Flexible-Dose Study of Paliperidone Palmitate in
Nonacute But Symptomatic Patients With Schizophrenia
Previously Unsuccessfully Treated With Oral
Antipsychotic Agents
1 2 3 4
Andreas Schreiner, MD ; Paul Bergmans, MSc ; Pierre Cherubin, PharmD ; Sofia Keim ;
5 6 7
Elmars Rancans, MD, PhD ; Yasin Bez, MD ; Eduard Parellada, MD, PhD ;
Bernardo Carpiniello, MD8 9 1
; Pierre Vidailhet, MD, PhD ; and Ludger Hargarter, MD
1 2
Medical Affairs, Janssen Cilag EMEA, Neuss, Germany; Biometrics and Reporting, Janssen Cilag
Benelux, Tilburg, the Netherlands; 3Medical Affairs, Janssen Cilag EMEA, Issy-les-Moulineaux, France;
4Global Clinical Operations EMEA MAO, Janssen Cilag, Barcarena, Portugal; 5Department of Psychiatry
and Narcology, Riga Stradins University, Riga, Latvia; 6Dicle University Medical Faculty, Diyarbakir,
7 ´
Turkey; Barcelona Clinic Schizophrenia Unit (BCSU), Hospital Clınic de Barcelona, University of
8 ` 9
Barcelona, Barcelona, Spain; Clinica Psichiatrica Universita di Cagliari, Cagliari, Italy; and Centre
´
Hospitalier Regional Universitaire de Strasbourg, Strasbourg, France
ABSTRACT (n ¼ 138 [23.3%]), and lack of tolerability (n ¼ 5
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