原创力文档a prospective study of community-associated clostridium difficile infections the role of antibiotics and co-infections：社区相关的难辨梭状芽孢杆菌感染的抗生素和感染作用的前瞻性研究.pdfVIP
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a prospective study of community-associated clostridium difficile infections the role of antibiotics and co-infections：社区相关的难辨梭状芽孢杆菌感染的抗生素和感染作用的前瞻性研究
Journal of Infection (2014) 69, 134e144
/journals/jinf
A prospective study of community-
associated Clostridium difficile infections:
The role of antibiotics and co-infections
Surabhi K. Taori a,*, Allison Wroe a, Alison Hardie b,
Alan P. Gibb c, Ian R. Poxton a
a Microbial Pathogenicity Research Laboratory, Medical Microbiology, The Chancellors Building,
University of Edinburgh, 49, Little France Crescent, Edinburgh EH16 4SB, UK
b Specialist Virology Centre, Royal Infirmary of Edinburgh, 51, Little France Crescent, Edinburgh EH16
4SA, UK
c Department of Clinical Microbiology, Royal Infirmary of Edinburgh, 51, Little France Crescent,
Edinburgh EH16 4SA, UK
Accepted 16 April 2014
Available online 26 April 2014
KEYWORDS Summary Objectives: This prospective study was performed to determine the incidence,
Antibiotic associated risk factors, severity and outcomes of community-associated Clostridium difficile infection
diarrhoea; (CA-CDI) in the SE of Scotland.
Anaerobic infections Methods: All patients (335) diagnosed with laboratory confirmed CDI in the city of Edinburgh,
East Lothian and Midlothian regions of Scotland between August 2010 and July 2011 were fol-
lowed up for one year after diagnosis. Clinical details and laboratory markers were recorded.
Stool samples were tested for C. difficile, other bacterial pathogens and norovirus. Molecular
epidemiology of C. difficile isolates was studied by PCR-ribotyping.
Results: Of the total 335 confirmed CDI cases, PCR-ribotype 001 was the commonest (14.1%),
followed by PCR-ribotypes 078 (12.9%
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