a randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in laos：一种口服氯霉素与简单的伤寒在老挝氧氟沙星治疗随机对照研究.pdfVIP

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a randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in laos：一种口服氯霉素与简单的伤寒在老挝氧氟沙星治疗随机对照研究.pdf

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a randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in laos：一种口服氯霉素与简单的伤寒在老挝氧氟沙星治疗随机对照研究

Transactions of the Royal Society of Tropical Medicine and Hygiene (2005) 99, 451—458 A randomized comparison of oral chloramphenicol versus oﬂoxacin in the treatment of uncomplicated typhoid fever in Laos Simmaly Phongmany a,b, Rattanaphone Phetsouvanha,b, Siho Sisouphone a,b, Chirapha Darasavatha,b, Pankham Vongphachanea,b, Oudayvone Rattanavong a,b, Mayfong Mayxay b,c, Andrew C. Ramsay b,d,e, Stuart D. Blacksell b,d,e, Chanpheng Thammavonga,b, Bounkong Syhavonga,b, Nicholas J. White b,d,e,∗, Paul N. Newton b,e a Mahosot Hospital, Vientiane, Laos Wellcome Trust-Mahosot Hospital, Oxford Tropical Medicine Research Collaboration, Vientiane, Laos c Faculty of Medicine, National University of Laos, Vientiane, Laos d Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand e Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford OX3 7LJ, UK Received 26 February 2004; received in revised form 2 August 2004; accepted 5 August 2004 KEYWORDS Summary We conducted a randomized open trial of oral chloramphenicol Typhoid; (50 mg/kg/day in four divided doses for 14 days) versus oﬂoxacin (15 mg/kg/day in Salmonella Typhi; two divided doses for 3 days) in 50 adults with culture-conﬁrmed uncomplicated ty- Chloramphenicol; phoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2—30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, Oﬂoxacin; four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Clinical trial; Median (range) fever clearance times were 90 (24—224) hours in the chlorampheni- Laos col group and 54 (6—93) hours in the