a randomized controlled trial of allopurinol in patients with peripheral arterial disease:外周血管疾病患者别嘌呤醇的随机对照试验.pdfVIP
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a randomized controlled trial of allopurinol in patients with peripheral arterial disease:外周血管疾病患者别嘌呤醇的随机对照试验
Canadian Journal of Cardiology - (2015) 1e7
Clinical Research
A Randomized Controlled Trial of Allopurinol in Patients With
Peripheral Arterial Disease
Alan J. Robertson, MD, and Allan D. Struthers, MD
Division of Cardiovascular and Diabetes Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom
ABSTRACT RESUME
Background: Patients with peripheral arterial disease (PAD) are Introduction : Les patients atteints d’une maladie arterielle peripherique
limited by intermittent claudication in the distance they can walk. (MAP) sont limites par une claudication intermittente dans la distance
Allopurinol has been shown in coronary arterial disease to prolong qu’ils peuvent parcourir. Il a ete demontre que lors de maladie coro-
exercise before angina occurs, likely by prevention of oxygen wastage narienne l’allopurinol prolonge la periode d’exercice avant que n’appar-
in tissues and reduction of harmful oxidative stress. aisse l’angine, probablement par la prevention des pertes d’oxygène dans
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