a randomized trial of mycobacterium w in severe sepsis：严重脓毒症中结核分枝杆菌的随机试验.pdfVIP

Journal of Critical Care 30 (2015) 85 –89 Contents lists available at ScienceDirect Journal of Critical Care j ournal homepage : www.j A randomized trial of Mycobacterium w in severe sepsis Inderpaul Singh Sehgal 1, Ritesh Agarwal ⁎, 1, Ashutosh N. Aggarwal 1, Surinder K. Jindal 1 Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India a r t i c l e i n f o a b s t r a c t Keywords: Purpose: The aim of this study was to evaluate the efficacy of Mycobacterium w (Mw), an immunomodulator in Mycobacterium indicus pranii severe sepsis. Septicemia Methods: Patients 18 years or older with severe sepsis were randomized within 48 hours of first organ dysfunc- Septic shock tion to receive either intradermal Mw or saline. The primary end point was 28-day mortality, whereas the sec- Mycobacteria ondary end points were ventilator days, intensive care unit (ICU) and hospital length of stay, and delta Bacteremia Antibiotics Sequential Organ Failure Assessment (SOFA) score. Results: Fifty patients with severe sepsis (25 Mw, 25 control) were included in the study. There were 7 and 8 deaths in the Mw and control groups, respectively (P = 0.51). The days on mechanical ventilator were signifi-