原创力文档a randomized double-blind study evaluating anandron associated with orchiectomy in stage d prostate cancer：一项随机双盲研究评价尼鲁米特与d期前列腺癌去势相关.pdfVIP
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a randomized double-blind study evaluating anandron associated with orchiectomy in stage d prostate cancer：一项随机双盲研究评价尼鲁米特与d期前列腺癌去势相关
J. SteroidBiochem. Molec. Biol. Vol. 37, No. 6, pp. 909-915, 1990 0960-0760/90 $3.00 + 0.00
Printed in Great Britain. All rights reserved Copyright © 1990 Pergamon Press plc
A R A N D O M I Z E D DOUBLE-BLIND STUDY E V A L U A T I N G
A N A N D R O N ® ASSOCIATED WITH O R C H I E C T O M Y IN
STAGE D PROSTATE C A N C E R
M. NAMER, l * J. TOUBOL,2 A. CATY, 3 J. E. COUETTE,4 J. DOUChEZ, 5 P. KERBRAT6
and J. P. DROZ 7
~CentreAntoine Lacassagne, 36, Voie Romaine,06054Nice Cedex,2H6pitalPasteur, 06002Nice Cedex,
3Centre Oscar Lambret, 59020 Lille Cedex, 4Centre Franqois Baclesse, 14021 Caen Cedex; 5Centre
Claudius Regaud, 31052 Toulouse Cedex, 6CentreEug6ne Marquis, 35011 Rennes Cedex and 7Institut
Gustave Roussy, 94805 VillejuifCedex, France
Summary--Arandomized double-blind study with a 3-yr follow-up comparing the two arms
orchiectomy + Anandron (300 mg) vs orchiectomy + placebo in 125 patients with stage
D prostate cancer has confirmed the beneficial effects of the combined Anandron ~ therapy
on subjective parameters and on the best objective response (NPCP criteria), although these
effects were not statistically significant, but failed to detect any improvement in time-to-disease
progression or survival. Comparison with the results of other trials emphasizes the urgent need
to establish suitable prognostic factors by further clinical research before evaluating the
benefits of individual drugs.
I N T R O D U C T I O N
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