MicroRNA调控动物脂肪细胞分化的研究进展.pdfVIP

Hereditas (Beijing) 2015 年 12 月, 37(12): 1175―1184 综 述 MicroRNA 调控动物脂肪细胞分化研究进展 张进威，罗毅，王宇豪，何刘军，李明洲，王讯 四川农业大学动物科技学院，动物遗传育种研究所，成都 611130 摘要:脂肪组织不仅在维持机体能量代谢和稳态上发挥重要作用，同时也是重要的内分泌器官。脂肪细胞分化 是由间充质干细胞(Mesenchymal stem cells, MSC) 向成熟脂肪细胞分化的复杂生理过程，该过程由大量转录因子、 激素、信号通路分子协同调控。miRNA 作为内源性非编码RNA ，主要通过抑制转录后翻译等机制来调控基因 表达。近年来越来越多的证据表明 miRNA 通过调控脂肪细胞分化相关的转录因子和重要信号分子进而影响动 物脂肪细胞的分化和脂肪形成。本文对miRNA 影响动物白色、棕色和米色脂肪细胞分化的作用机制及其相关 调控通路和关键因子进行了归纳总结，以期为肥胖等代谢性疾病的治疗提供一定的理论指导和新的治疗思路。 关键词:miRNA；白色脂肪细胞；棕色脂肪细胞；米色脂肪细胞；分化 MicroRNA regulates animal adipocyte differentiation Jinwei Zhang, Yi Luo, Yuhao Wang, Liujun He, Mingzhou Li, Xun Wang College of Animal Science and Technology, Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China Abstract: Adipose tissues play a critical role in the regulation of energy metabolism and homeostasis, and is also an important endocrine organ. Adipocyte differentiation is a complicated physiological process during which mesenchymal stem cells differentiate into adipocytes. This process is synergistically regulated by a large number of transcription factors, hormones and signaling pathway molecules. As a class of endogenous non-coding RNA (ncRNA), microRNAs (miRNAs) regulate gene expression mainly through post-transcriptional translational repression. In recent years, numerous studies have demonstrated that miRNA could have an impact on adipocyte differentiation and adipogenesis by modulating the ex- pression levels of several adipogenic transcription factors and key signaling molecules. In this review, we summarize the mechanism of miRNA in regulating the differentiation of white/brown/beige adipocytes and the relevant signaling pathways and key factors, in the hope of providing theoretical guidance and new thoughts for treating obesity and other metabolic diseases.