羧甲基壳聚糖_纳米羟基磷灰石复合支架材料的制备和生物安全性_王海斌.pdfVIP

DOI :10.13801/ki .fhclxb.2008.06.033 25 　6 　　12 　2008 Acta Mater iae Comp ositae Sin ica Vol.25 No.6 December 2008 :1000-3851(2008)06-0088-05 / ＊ 王海斌, 赫淑倩, 赵冬梅 , 孙康宁, 刘爱红 (, 250033) 　:　/(CMCT /n-HA ) , (n-H A);, 16.7%() , CMCT /n-HA 。, 。CMCT /n-HA 75%, 600 μm, , 21 MPa , , 。CMCT /n-HA 。 :　;;; :　R318.08　　:A Preparation and biology security of the porous carboxymethyl chitosan/ nano hydroxyapatite scaffold biocomposites ＊ WANG Haibin, HE huqian, ZHAO Dongmei , UN Kangning, LIU Aihong (The econd H ospital of handong University, Jinan 250033, China) Abstract:　To investigate the preparation and the biology security of the porous carboxymethyl chitosan/nano hydroxyapatite(CMCT /n-HA)scaffold biocomposites, the porous biocomposites of CMCT /n-HA were prepared by means of the porogen leaching method.In the process, anhydrous ethanol w as the porogen leaching solvent and citric acid was the sticky solvent.CMCT /n -HA were characterized by EM, the porosity and compressive strength were also tested.At the same time, changes of the bone histology and the detecting function of liver and kidney w ere observed by implanting CMCT /n-HA into the bone defects of rabbits.The porosity ratio of CMCT / n-HA is about 75% and the compressive strength can exceed 21 MPa.The diameter of the pores is about from several microns to six hundred microns and most of them are circular, w hich profits the grow th and extension of many tissues.The animal experiments show that CMCT /n-H A did not result in inflammatory reaction and bone putrescence and toxicity of liver and kidney.It is sugge