Nampt基因表达调控机制.pdf

HEREDITAS (Beijing) 2012 12 , 34(12): 1561―1569 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2012.01561 Nampt 基因表达调控机制 1 1 2 1 1 黄锐 , 王子茹 , 孙宇 , 张刚, 鲁亚平 1. , 241000; 2. , 200032 烟酰胺磷酸核糖转移酶(NAMPT)是烟酰胺腺嘌呤二核苷酸(NAD) 生物合成途径的关键限速酶, 也被称 为内脏脂肪素(Visfatin)或前B 细胞克隆增强因子(PBEF) 。它通过调节机体或细胞的NAD 水平以及通过其他非 酶机制等途径影响代谢、炎症反应、细胞的增殖、分化和凋亡, 特别是衰老等诸多过程。文章简要综述了近年 来Nampt 基因的表达调控及其转录的反馈调节机制研究进展。 Nampt 基因; 表达调控; 反馈调节 Mechanism of Nampt gene expression regulation 1 1 2 1 1 HUANG Rui , WANG Zi-Ru , SUN Yu , ZHANG Gang , LU Ya-Ping 1. College of Life, Anhui Normal University , Wuhu 241000, China; 2. Department of Pharmacology, Shanghai Medical College, Fudan University, Shanghai 200032, China Abstract: Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B cell colony-enhancing factor (PBEF) or visfatin, is a crucial rate-limiting enzyme of NAD biosynthetic pathway. It may affect the metabolism, inflammatory response, cell proliferation, differentiation, and apoptosis, especially the aging and other physiological progresses through regulating NAD biosynthesis and nonenzyme routes in the organisms and cells. This review mainly focuses on recent pro- gresses in the expression modulation and feedback regulation of Nampt gene. Keywords: Nampt gene; expression regulation; feedback regulation (Nicotinamide phospho- NAD Nampt ribosyltransferase, NAMPT) nadV, 2002 Rongvaux , [3]NAMPT 1957 NAD , NAD, , , [1] 2001 ,