哺乳动物Hippo信号通路：肿瘤治疗的新标靶.pdfVIP

HEREDITAS (Beijing) 2012 3 , 34(3): 269―280 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2012.00269 哺乳动物Hippo 信号通路：肿瘤治疗的新标靶 许传铭, 万福生 , 330006 Hippo 信号通路是首次在果蝇中发现具有调节细胞增殖与凋亡作用的信号通路。最近发现果蝇Hippo 信 号通路的组成、分子作用机制和生物学功能在进化过程中高度保守。Hippo 信号通路在胚胎发育中对细胞的生 长分化、组织器官形成以及成体干细胞的维持和自稳态的保持等方面具有重要作用。同时, Hippo 信号通路与 Wnt 信号通路、Notch 信号通路等相互作用、密切联系, 在肿瘤的发生、发展过程中也起到关键作用。文章综 述了哺乳动物Hippo 信号通路的作用机理、与其他信号通路和蛋白质因子的相互联系及与肿瘤的关系, 对于肿 瘤的诊断、预防和治疗具有一定的参考价值。 哺乳动物; Hippo 信号通路; 肿瘤 Hippo signaling pathway in mammals ：a new therapeutic target for tumors XU Chuan-Ming, WAN Fu-Sheng Department of Biochemistry and Molecular Biology, Basic Medical College of Nanchang University, Nanchang 330006, China Abstract: Hippo signaling pathway was first discovered in Drosophila as regulator of cell proliferation and apoptosis during development. It has been widely reported that Hippo signaling pathway plays an essential role in embryonic differ- entiation, pattern formation and adult cell homeostasis. Furthermore, Hippo signaling has close correlation with Wnt and Notch signaling pathways, and has an important effect on tumor initiation and progression. Recent studies have shown that the Drosophila Hippo signaling pathway is highly conserved over evolutionary time, the mammalian Hippo signaling path- way has been implicated in regulating cell contact inhibition, organsize and tumorigenesis. This review firstly focuses on the composition, regulatory mechanism and physiological functions of mammalian Hippo signaling pathway, and then lists the relationship with other signaling pathways and protein factors, and tumors in mammals. Finally, the therapeutic ap- proaches to targeting Hippo signaling pathway comp