微波辐射下一锅法合成2-氨基-6-溴-4-芳基-5H-茚并[1,2-b]吡啶-3-腈衍生物.pdfVIP

2010 年第 30 卷 有 机 化 学 Vol. 30, 2010 第 2 期, 233～237 Chinese Journal of Organic Chemistry No. 2, 233～237 ·研究论文· 微波辐射下一锅法合成 2-氨基-6-溴-4-芳基-5H-茚并[1,2-b]吡啶- 3-腈衍生物 季春香 a 薛永震 b 王建强 a 殷 俊 a 崔永涛 a 郭 成*,a (a 南京工业大学理学院 南京 210009) (b 南京化工研究院 南京 210033) 摘要 以芳香醛、4-溴茚酮、丙二腈和醋酸铵为原料, 分别用微波辐射和传统加热法, 一步法合成 7 种未见文献报道的 2-氨基-6-溴基-4-芳基-5H-茚并[1,2-b]吡啶-3-腈衍生物. 对比两种方法, 在常压下微波具有反应时间短、产率较高等特 点. 所有化合物均经 IR, 1H NMR 和元素分析确定. 关键词 4-溴茚酮; 微波辐射; 茚并[1,2-b]吡啶; 传统加热 One-Pot Synthesis of 2-Amino-6-bromo-4-(substituted phenyl)-5H- indeno[1,2-b]pyridine-3-carbonitrile Derivatives under Microwave Irradiation Ji, Chunxianga Xue, Yongzhenb Wang, Jianqianga Yin, Juna Cui, Yongtaoa Guo, Cheng*,a (a College of Sciences, Nanjing University of Technology, Nanjing 210009) (b Nanjing Institute of Chemical Industry, Nanjing 210033) Abstract Seven new 2-amino-6-bromo-4-(substituted phenyl)-5H-indeno[1,2-b]pyridine-3-carbonitrile de- rivatives were synthesized by using benzaldehydes, 4-bromo-indan-1-one and malononitrile in one-pot via conventional heating and microwave irradiation techniques. By comparison of the two methods, the micro- wave irradiation possessed such advantages as short reaction time, high yields and so on over the conven- 1 tional method under norma