中药联合腔内理对FET周期肾虚患者子宫内膜容受性及HB-EGF的影响.pdfVIP

疗组。（11）两组患者妊娠率差异有统计学意义（P＜0.05），腔疗组高于非腔疗组。 结论：中药联合腔内理疗能够改善肾虚型不孕患者冻融胚胎移植周期的肾虚临床 症状，改善子宫局部环境，降低子宫内膜血流阻力，改善子宫内膜血供，增加子宫内 膜厚度，提高子宫内膜HB-EGF mRNA表达水平，从而改善子宫内膜容受性，提高临床 妊娠率，优于单用中药治疗。 关键词 腔内理疗；冻融胚胎移植(FET)；肾虚；肝素结合性表皮生长因子 （HB-EGF）；子宫内膜容受性 The impact of Chinese herbal medicine and Intracavitary physiotherapy on Endometrial reception and HB-EGF of kidney deficiency patients in frozen-thawed embryo transfer treatment cycle Speciality: Gynecology of TCM Author: Sun Limin Tutor: Pof. Lian Fang Abstract Objective: To observe the effect of Chinese herbal medicine and Intracavitary physiotherapy on the expression of endometrial heparin-binding EGF-like growth factor(HB-EGF) and endometrial receptivity of kidney deficiency patients in frozen-thawed embryo transfer treatment cycle，and explore the mechanism of Chinese herbal medicine and Intracavitary physiotherapy in improving endometrial receptivity and the clinical pregnancy rate. Methods: 1.the retrospective study: Retrospective analysis was made on 207 FET cycles in 207 kidney deficiency patients from February 2001 to December 2010.The patients were divided into 2 groups :one was Intracavitary physiotherapy treatment group ,treated with Intracavitary physiotherapy while given Chinese herbal medicine (105 cases),and another was not Intracavitary physiotherapy treatment group, treated with Chinese herbal medicine (102 cases).The relationship between pregnancy rate of FET and following factors were analyzed :age ,the endometrial thickness, the number of transferred embryos , the embryo morphology score and pregnancy rate. 2.clinical re