参松养心胶囊治缓慢性心律失常疗效和安全性的Meta分析.pdfVIP

Efficacy and Safety of ShenSongYangXin capsule for Slow Arrhythmia:a Meta-analysis Speciality:Internal Medicine of Traditional Chinese Medicine Author:Tan Tong Tutor:Professor You Ke Abstract Objective: To evaluate the clinical efficacy and safety of ShenSongYangXin capsule on slow arrhythmia. Methods: We retrieved CNKI ,VIP, WANFANG, PubMed, the Cochrane Library of clinical control trial databases and other databases by computer.According to the integration and elimination standard of the literature,We chose the randomized controlled trials (RCTs) of ShenSongYangXin capsule on slow arrhythmia.Two reviewers finished the quality assessment independently,extracted the data and cross checked. Then we used the RevMan 5.0 software for the Meta-analysis. Results: A total of 14 studies included 1121 cases of patients, the quality of its research was low quality. Meta-analysis results showed that: compared with the control group ,(1) 14 of the clinical efficacy of the efficiency of the combined effect of the test: OR combined=5.06,95% CI was [3.75,6.84],Meta-analysis of results was statistically significant(P 0.00001);(2)24h Holter efficacy in two studies the efficiency of the combined effect of the amount of test: OR combined=6.72,95% CI was [2.85,15.86](P 0.0001),24h Holter effect of ShenSong capsule was better than the control group;(3)6 studies reported the average heart rate increase by comparing with the control group.Due to 2 the heterogeneity test,P 0.00001,I =76%,so we chose the random effects model analysis and the results showed that:MD=7.10,95% CI was [5.47,8.73] (P 0.00001), the average hea