凉血消斑饮治疗tp的临床观察及动物实验研究.pdfVIP

The Clinical Observation and Animal Experiments of The Therapy of Liangxuexiaoban Formula to Idiopathic Thrombocytopenic Purpura Speciality: Internal Medicine of Integrated TCM Auther: Sun Sisi Tutor: Prof ．Xu Ruirong ABSTRACT Objective:To observe the effect of Liangxuexiaoban Formula to the clinical symptoms and and the level of peripheral platelet count, IL-18 of ITP patients, and to the platelet count, bleeding time, megakaryocyte and the level of IL-18 in peripheral blood serum of ITP mice. Further to discusse the effects of TCM mechanism and the relationship of IL -18 and ITP. Methods: Clinical observation: Totally 40 ITP patients were randomized into treatment group (20 patients, receiving Liangxuexiaoban Formula therapy) and control group (20 patients , receiving Weixuening particles therapy). Two groups of course are 2 months and then to observe the changes of the above indexes. Animal experiments: Using the immune modeling method of intraperitoneal injection of cavy-anti-mouse platelet serum (APS) to establish BALB/C mice with ITP, Liangxuexiaoban Formula have researched comparing with Weixuening particles as the positive control group to observe the changes of the above indexes. Results: Clinical observation: The total efficacy rate of treatment group was 85% , compared to 80% in control group, and the curative effect had siginificant deviation between two groups (P0.05). The post-treatment platelet count was increased significantly in two groups, and there was siginificant deviation compared to the pre-treatment (P0.05). The post-treatment platelet count was siginificant deviation