耳背静脉放血治无先兆偏头痛止痛效应观察及对家兔模型pag区c-fos表达、g蛋白含量的影响.pdfVIP

Observation of the analgesic effect of the migraine without aura patients and effect in c-fos expression and content of G protein of the rabbit model in PAG by era vein’s bloodletting Specialty:Acupuncture and moxibustion Author:kan Junzhen Tutor:Yang Dianhui Abstract Objective:To observe the instant effect and clinical evaluation of the migraine without aura patients by bloodletting via era vein,and explore the mechanisms through the point of view of c-fos and G protein in PAG. Method:The clinical trials:the 30 patients who met the inclusion criteria was treated by giving bloodletting via era vein,and observed the changes in pain intensity before and after the first treatment,and clinical evaluation after a course of treatment.Animal experiments:By the way of random and control trial,30 New Zealan rabbits were randomly averaged into three groups,treatment group,model group and blank group,each group of 10 only.Bled the two ears of rabbits in treatment group after the model.The model group model only,not treatde.The blank group did not deal with.Then determined rabbit model c-fos expression and content of G protein in PAG. Result:① bloodletting via era vein on the attack of migraine without aura patients had instant efficacy obvious(P0.01)and clinical evaluation significant(P0.01),the effective rate was 93.33%;bloodletting via era vein can restrain c-fos expression visibly and reduce the content of G protein(P0.01). Key words the migraine without aura;bloodletting via era vein;rabbit model;c-fos gene;G protein 目 录 引 言 1 临床研究 2 一、临床资料 2 （一）病例选择标准 2 （二）一般情况 3 二、研究方法 3 （一）治疗方法 3 （二）观察指标 4 （三）疗效评定 4 （四）统计方法 5 三、研究结果 5 （一）即刻止痛效果