肾衰方对慢性肾能衰竭湿热证患者no、tnf-α水平的影响研究.pdfVIP

目 录 中文摘要·····················································1 英文摘要 ·····················································2 引 言 ······················································4 正 文 ······················································7 1．研究对象与方法 ··········································7 1.1 研究对象 ················································7 1.2 诊断辬准 ·················································7 1.3 疗效评定辬准 ·············································8 1 . 4 实 验 病 例 辬 准 ·················································9 1.5 治疗方法 ·················································11 1.6 观察指辬 ·············································11 1.7 统计学方法 ···············································13 2 ． 结 果 ··················································13 3 . 讨 论 ··················································17 结 论 ·····················································39 参考文献 ····················································40 综 述 ·····················································48 致 谢 ·····················································57 攻读学位期间发表的学术论文目录 ······························58 作者声明 ····················································59 个人简历 ····················································60 中 文 摘 要 目 的:观察具有清热化湿，和胃止呕作用的肾衰方治疗慢性肾功能衰竭 湿热证的临床疗效，并初步探讨其作用机理。同时检测了两个目前公认 的研究指辬NO （一氧化氮）和TNF- α（肿瘤坏死因子- α），以观察他们 在调节肾脏生理和病理方面的作用。 方 法:按慢性肾功能衰竭(CRF)诊断辬准，选择符合诊断的 CRF 湿热证 患者60 例，按就诊先后随机分成治疗组和对照组各 30 例，在常规治疗 基础上，分别予以肾衰方和药用炭片口服，8 周为一个疗程，一个疗程后， 观察治疗前后各组指辬、体征及中医证候的改善情况，并评价临床疗效 和对TNF- α及NO 的影响。 结 果:治疗前后相比，治疗组总有效率为 83.3%，对照组总有效率为 53.3%，治疗组疗效优于对照组，经统计学分析，组间比较有显著性差异 （P 0.05 ），两组中医证候疗效相比差异显著（P 0.05 ），治疗组的TNF- α及NO 变化显著（P 0.05 ），差异均有统计学意义。 结 论:肾衰方能