加味柴芍六君颗对溃疡性结肠炎患者外周血T淋巴细胞亚群的影响研究.pdfVIP

目 录 中文摘要 ···················································1 英文摘要 ···················································3 引 言 ····················································5 主要缩略词对照表 ·········································6 正 文 ····················································7 1.理论研究 ·················································7 1.1 中医古典文献对溃疡性结肠炎的认识··························7 1.2 西医对UC病因病机的认识 ···································8 2.临床研究 ···············································11 2.1 研究方法 ···············································11 2.2 试验设计及方法 ··········································15 3.结果 ····················································18 4.讨论 ····················································21 结 语 ··················································31 参考文献 ·················································33 附 录 37 综 述 ··················································39 致 谢 ··················································49 攻读学位期间发表的学术论文目录 ·······················50 作者声明 ··················································51 个人简历 ··················································52 中 文 摘 要 目 的：观察加味柴芍六君颗粒治疗溃疡性结肠炎的疗效以及对外周血 T 淋巴细胞亚群的影响，并从理论和临床研究方面探讨加味柴芍六君颗粒 治疗溃疡性结肠炎的作用机理，从而为其作为中药治疗的临床推广应用 提供客观的科学依据。 方 法：1.本课题以《中药新药临床指导原则》中药新药治疗慢性非特 异性溃疡性结肠炎的临床研究指导原则为具体参照标准进行严格的临床 研究设计，结合具体临床实际，采用随机对照的方法，以广西中医学院 第一附属医院的门诊和住院患者为研究对象，依据2000 年成都全国炎症 性肠病学术研讨会制定的溃疡性结肠炎的诊断标准，选择溃疡性结肠炎 病例60 例。 2. 治疗组予加味柴芍六君颗粒，对照组予柳氮磺胺砒啶片 （SASP ） （4g/d ）治疗，疗程均为8 周，分别进行安全性观察(一般体检项目、血 尿便三大常规化验、心肝肾功能检查、可能出现的不良反应)和疗效性观 察包括（1 ）临床综合疗效，中医证候疗效，临床主要症状（腹泻、便血、 腹痛）变化、内镜粘膜疗效等（2 ）两组治疗前后的免疫学指标变化：外 ＋ ＋ ＋ ＋ ＋ ＋ 周血 CD4 /CD8 /CD3 细胞，外周血 CD4 /CD8 /CD3 细胞用流式细胞 仪检测。 3.分别比较两组治疗前后中医症状总积分、治疗后综合疗效、治疗前 后各临床症状积分、治疗前后肠镜粘膜病变疗效的情