地黄管食通口服对食管癌放疗患者生活质量及血清IL-6和IL-10的影响.pdfVIP

地黄管食通口服液对食管癌放疗患者生活质量及血清 IL-6 和 IL-10 的影响 质量方面的优越性，在一些方面弥补了放疗的不足和缺陷。并能在一定程度上调整紊 乱的细胞因子，促进机体免疫向 Th1 方向漂移，使机体免疫平衡正向移动，提高机体 的免疫功能，增强机体抗肿瘤的能力，提示地黄管食通口服液具有平衡机体免疫力的 作用。 关键词：地黄管食通口服液；食管癌放疗患者；生活质量；IL-6；IL-10 - 2 - 摘要 The Influence of Dihuangguanshitong Oral Liquid on the Quality of Life and IL-6、IL-10 Of Esophageal Carcinoma Patients with Radiotherapy ChenLi （Internal Medicine of Traditional Chinese Medicine ） Directed by Zheng Yuling Abstract Objective:Observed the influence of Dihuang guan shi tong oral liquid on quality of life and IL-6, IL-10 in blood serum of esophageal carcinoma patients with radiotherapy and evaluated its clinical effect. We aim to offer the foundations for clinical using and extending this drug. Methods:60 cases of esophageal carcinoma patients with radiotherapy which were fit- ting selected standard were randomly divided into control group and treatment group. Treat- ment group patients were given radical cure radiation therapy while taken Dihuangguanshi- tong oral liquid 3 times a day 10ml each time. Four weeks was a course, observation lasted two courses. The control group was given the pure radical cure radiation therapy. The diver- sification on quality of life before and after 1、2 treatment courses were observed, respec- tively. EORTC QLQ-C30 (V3.0) and EORTC QLQ-OES18 were adopted to questionnaire investigate and kept the scores. The levels ofIL-6 andIL-10 in blood serum were tested at the same time by ABC-ELISA method and data were compared. All data were expressed by mean ±standard deviation and analysed by SPSS13.0 statistic software. Results:For QOL,the results of EORTC QLQ-C30 showed that DOL group could obv