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安胃汤对胃溃疡鼠血清瘦素、TGF-α、NO的影响
目 录
中文摘要 ················································1
英文摘要 ················································3
引 言 ·················································5
正 文 ·················································6
1. 实验材料和方法 ··········································6
1.1 实验材料 ···············································6
1.1.1 动物 ·················································6
1.1.2 药物与试剂 ···········································6
1.1.3 主要仪器设备 ·········································6
1.2 实验方法 ··············································6
1.2. 1 实验动物分组·········································6
1.2.2 实验性大鼠胃溃疡模型的制备 ···························7
1.2.3 给药 ·················································7
1.2.4 标本采集及处理 ·······································8
1.2.5 溃疡指数的测量和计算 ·································8
1.2.6 HE染色方法 ··········································9
1.2.7 再生粘膜厚度、粘膜肌层缺损度的测定 ···················9
1.2.8 瘦素、TGF- α、NO 的检测方法 ·························9
1.2.9 统计学方法 ············································11
2. 实验结果··················································11
2.1 动物外观观察 ···········································11
2.2 胃窦大体形态观察········································11
2.3 各组溃疡指数的比较 ·····································12
2.4 HE 染色的组织形态结构观察 ·······························12
2.5 各组再生粘膜厚度、粘膜肌层缺损度的比较···················13
2
2.6 瘦素、TGF- α、NO 各指标的检测 ·························14
3. 讨 论 ·················································14
3.1 现代医学对消化性溃疡的认识 ····························14
3.2 现代医学治疗消化性溃疡的对策及现状 ···················16
3.2.1 临床上常用的抑制胃酸分泌的药物 ······················16
3.2.2 抗 HP 感染治疗 ······································17
3.2.3 胃粘膜保护剂········································18
3.3 关于瘦素、TGF- α、NO 的讨论····························19
3.4 中医对消化性溃疡的认识 ··················
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