生物机械力启动的血管重塑和平滑肌细胞信号传导PPT课件.pptVIP

* Biomechanical Stress-initiated Vascular Remodeling and Signal Transduction in Smooth Muscle Cells Department of Histology Embryology School of Basic Medical Sciences Zhongshan University GUANGZHOU, P.R.CHINA Chaohong Li 李 朝 红 中山大学基础医学院组胚教研室 Page 85 Sympathetic nervous system Vascular remodeling (arteriosclerosis) Heart remodeling (heart failure) Main Causes to Mortality and Morbidity Hypertension Biomechanical stresses Renin-angiotensin system HYPOTHESIS-DRIVEN WORKING MODEL Biomechanical Stress Stretch stress: created by blood pressure Shear stress: created by fluid f